A seizure represents an extreme deviation from normal brain activity. In this talk, we will consider some characteristics of the seizure as observed across spatial and temporal scales in human patients. We will focus specifically on changes in the rhythmic voltage activity, and consider techniques to characterize these changes. We will also discuss a mathematical model consistent with the stereotyped dynamics observed at seizure termination, and use this model to propose what happens dynamically when a seizure fails to self- terminate.