Videos

Design Principles in Synthetic Biology

Presenter
April 24, 2008
Keywords:
  • Biology
MSC:
  • 97M60
Abstract
Recently, numerous engineers have demonstrated that genetic circuits can be effectively modeled and analyzed utilizing methods originally developed for electrical circuits leading to new understanding of their behavior. If this is possible, then it may also be possible to design synthetic genetic circuits that behave like particular electrical circuits such as switches, oscillators, and communication networks. Synthetic genetic circuits have the potential to help us better understand how microorganisms function, produce drugs more economically, metabolize toxic chemicals, and even modify bacteria to hunt and kill tumors. There are, however, numerous challenges to design with genetic material. For example, genetic circuits are composed of very noisy components making their behavior more asynchronous, analog, and non-deterministic in nature. Therefore, design methods must be adapted to consider these issues. Interestingly, future electrical circuits may soon also face these challenges which opens up the very intriguing idea that these new design methods may in the future be utilized to produce more robust and power efficient electrical circuits.