Over the last three decades computer simulation have been able to bring atomic motion to structural biology. Such motion is not seen in experimental structural studies but is relatively easily studied by applying law of motions to models of the proteins and nucleic acids. By bringing molecular to life in this way, simulation complements experimental work making it is much easily to understand how proteins biological macromolecules function. After introducing molecular structure and the fundamental forces that stabilize it, we consider molecular motion and protein folding. Lecture 1 will introduce fundamental forces between atoms and consider how these forces give rise to the stable protein structures.