A. Quantitation of local, sequence-dependent properties of DNA Low resolution models, including knowledge-based potentials Linear, sequence-dependent three-dimensional structures B. Effects of sequence on ring closure properties of closed molecules Sequence-dependent factors that enhance the formation of tight minicircles and loops Mechanics of superhelix formation: roles of bending, twisting, and base-pair displacement Nucleotide looping and global folding of RNA C. Effects of sequence on the equilibrium structures and normal modes of cyclized DNA Constrains of bound proteins on global structure and motions Nucleosome positioning sequences and minichromosomes