A simple approach that enables us to analyse the interrelationships between Ca2+ handling processes at the cellular level and the role of intercellular communication in the emergence of multicellular synchronization is presented. Individual cells are represented by a mathematical model of intracellular Ca2+ dynamics, and coupled via Ca2+ currents and membrane potential. Theoretical predictions successfully reproduce experimental findings and provide novel insights on the action of several pharmacological agents that modulate Ca2+ signalling pathways and intercellular communication via distinct mechanisms.