Transport in neurons is intrinsically bidirectional, with each movement modality carried out by molecular motors in either the kinesin (anterograde) or the dynein (retrograde) families. Because all motors are present at a given time there must be competition and/or cooperation among motors that simultaneously bind a single vesicle to nearby microtubules. It has been assumed for much of the last decade that the competition must resolve itself though some kind of tug-of-war; but recent evidence shows conclusively that this is often not the case in vivo. In this talk, we will see a few biological mechanisms (and associated mathematical models) that may lead to resolving theory with experimental observations. Joint work with Will Hancock (Penn State), John Fricks (Penn State), and Pete Kramer (RPI).