In this talk I will focus on the role of vector dynamics and its ecological and economic implications for disease control. Genetic methods of controlling insects and agricultural pests have advanced in recent years but their economic benefits remain largely unexplored. By integrating epidemiological and economic approaches we can build sensible mathematical models for exploring the implications of vector control on levels of disease burden. In this talk I will illustrate the ways that we have approached this for understanding Dengue dynamics and some of the subtle ways that understanding human movement and flows are important for implementing disease invention strategies.