We examine the computational anatomy model, orbits of functional and structural imagery under the action of the diffemorphism group. A geodesic positioning system is described for positioning neuroanatomy within the orbit. The coordinates of the GPS will be examined, deriving methods for clustering and disease prediction on elements of the orbit. Applications to several neurodegenerative diseases, Alzheimer's and Huntington's will be presented. Results on the spatiotemporal flow of neurodegenerative disease associated to cortical and subcortical networks will be shown.