While extremely helpful and important, databases are intrinsically sterile repositories of information, unless rational descriptors are implemented for rapid identification of the materials genomics. In this talk we will give examples of descriptors (i.e. scintillation, photovoltaics, thermoelectricity, piezoelectricity, supermagnets, spintronics, catalysis, phase stability), and will introduce the concept of AFLOW genetic-daemons: the tools for automatic discovery of materials without human intervention