Keywords: 3D Navier-Stokes equations, multiscale atmospheric dynamics and turbulence, high resolution simulations. Abstract: High resolution multi-scale simulations of limited area atmospheric environments are one of the major frontiers of atmospheric sciences and environmental sustainability. The latest developments in high performance computing technologies represent an opportunity to advance and improve real time atmospheric characterization and forecasting over limited areas. Among the new capabilities required are improved physics based sub-grid parameterizations and one- or two-way nesting to integrate models of disparate scales. We present high resolution horizontally and vertically nested mesoscale/microscale simulations for effective resolution of multiscale atmospheric physics phenomena in regional atmospheres (A. Mahalov and M. Moustaoui, Journal of Computational Physics, vol. 228, p. 1294-1311, 2009).