Videos

Applications of monomial ideals and computational algebra in the reverse engineering of biological networks.

Presenter
September 19, 2006
Keywords:
  • Systems biology, networks
MSC:
  • 92C42
Abstract
he reverse engineering of biological networks is an important and interesting problem. Two examples of such networks are gene regulatory networks, and the relationship of voxels in the brain. We describe a method for determining possible "wiring diagrams" for such networks. The method is based on computational algebra, and a key part of the method uses computations involving monomial ideals in a polynomial ring. To illustrate the algorithms, we apply the method to data coming from fMRI scans of the brain. This talk represents joint work (on the arXiv at q-bio.QM/0605032) with Abdul Jarrah, Reinhard Laubenbacher, and Brandy Stigler. The analysis of the brain data was performed by Paola Vera.