Applications of monomial ideals and computational algebra in the reverse engineering of biological networks.
Presenter
September 19, 2006
Keywords:
- Systems biology, networks
MSC:
- 92C42
Abstract
he reverse engineering of biological networks is an important and
interesting problem. Two examples of such networks are gene
regulatory networks, and the relationship of voxels in the brain. We
describe a method for determining possible "wiring diagrams" for such
networks. The method is based on computational algebra, and a key
part of the method uses computations involving monomial ideals in a
polynomial ring. To illustrate the algorithms, we apply the method
to data coming from fMRI scans of the brain.
This talk represents joint work (on the arXiv at q-bio.QM/0605032)
with Abdul Jarrah, Reinhard Laubenbacher, and Brandy Stigler. The
analysis of the brain data was performed by Paola Vera.