In this talk, I will describe a novel approach to change-point detection when the observed high-dimensional data may have missing elements. The performance of classical methods for change-point detection typically scales poorly with the dimensionality of the data, so that a large number of observations are collected after the true change-point before it can be reliably detected. Furthermore, missing components in the observed data handicap conventional approaches. The proposed method addresses these challenges by modeling the dynamic distribution underlying the data as lying close to a time-varying low-dimensional submanifold embedded within the ambient observation space. Specifically, streaming data is used to track a submanifold approximation, measure deviations from this approximation, and calculate a series of statistics of the deviations for detecting when the underlying manifold has changed in a sharp or unexpected manner. The proposed approach leverages several recent results in the field of high-dimensional data analysis, including subspace tracking with missing data, multiscale analysis techniques for point clouds, online optimization, and change-point detection performance analysis. Simulations and experiments highlight the robustness and efficacy of the proposed approach in detecting an abrupt change in an otherwise slowly varying low-dimensional manifold. Rebecca Willett is an associate professor in the Electrical and Computer Engineering Department at the University of Wisconsin-Madison. She completed her PhD in Electrical and Computer Engineering at Rice University in 2005 and was an assistant then associate professor of Electrical and Computer Engineering at Duke University from 2005 to 2013. Prof. Willett received the National Science Foundation CAREER Award in 2007, is a member of the DARPA Computer Science Study Group, and received an Air Force Office of Scientific Research Young Investigator Program award in 2010. Prof. Willett has also held visiting researcher positions at the Institute for Pure and Applied Mathematics at UCLA in 2004, the University of Wisconsin-Madison 2003-2005, the French National Institute for Research in Computer Science and Control (INRIA) in 2003, and the Applied Science Research and Development Laboratory at GE Healthcare in 2002. Her research interests include network and imaging science with applications in medical imaging, neural coding, astronomy, and social networks.