Videos

Jonathan Rubin - dynamics to constrain connectivity of neuronal population in respiratory brainstem

Presenter
February 13, 2024
Abstract
Recorded 13 February 2024. Jonathan Rubin of the University of Pittsburgh presents "Using dynamics to constrain the connectivity of a neuronal population: a case study in the respiratory brainstem" at IPAM's Mathematical Approaches for Connectome Analysis Workshop. Abstract: In mammalian respiration, synchronized bursting activity of a select network of brainstem neurons drives the movement of the diaphragm that underlies inspiration. Experimental observations suggest that “pre-inspiratory” tonic spiking locally within this network may or may not ignite a widespread, synchronized activation, and when they do occur, these activations may manifest as small-scale burstlets or full-blown bursts. I will discuss two models related to this process, with an emphasis on a multi-state bootstrap percolation model that may provide insights about the connection architecture in this network, which is currently unknown. Learn more online at: https://www.ipam.ucla.edu/programs/workshops/mathematical-approaches-for-connectome-analysis/?tab=overview