We consider the set $\mathcal{M}_n(\mathbb{Z}; H))$ of $n\times n$-matrices with integer elements of size at most $H$ and obtain upper and lower bounds on the number of $s$-tuples of matrices from $\mathcal{M}_n(\mathbb{Z}; H)$, satisfying various multiplicative relations, including multiplicative dependence and bounded generation of a subgroup of $\mathrm{GL}_n(\mathbb{Q})$. These problems generalise those studied in the scalar case $n=1$ by F. Pappalardi, M. Sha, I. E. Shparlinski and C. L. Stewart (2018) with an obvious distinction due to the non-commutativity of matrices. As a part of our method, we obtain a new upper bound on the number of matrices from $\mathcal{M}_n(\mathbb{Z}; H)$ with a given characteristic polynomial $f \in\mathbb{Z}[X]$, which is uniform with respect to $f$. This complements the asymptotic formula of A. Eskin, S. Mozes and N. Shah (1996) in which $f$ has to be fixed and irreducible. Joint work with Igor Shparlinski.