We present several queueing-based optimization models to design networks in which the objective is to minimize the response time. The networks are modelled as collections of interdependent M/G/1 or M/G/K queueing systems with fixed and mobile servers. The optimization models take the form of nonconvex MINLP problems with fractional and bilinear terms. We derive a reformulation approach and propose a solution method that features a warm-start component, new optimality-based bound tightening (OBBT) techniques, and an outer approximation algorithm. In particular, we propose new MILP and feasibility OBBT models that can derive multiple variable bounds at once. The proposed approach is applied to the drone-based delivery of automated external defibrillators to out-of-hospital cardiac arrests (OHCA) and naloxone to opioid overdoses. The computational experiments are based on real-life data from Virginia Beach, and ascertain the computational efficiency of the approach and its impact on the response time and the probability of survival of patients.