We discuss the characterization of compactness for the sparse operator (associated with symbol in weighted VMO space) in the two-weight setting on the spaces of homogeneous type. As a direct application we obtain the compactness characterization for the maximal commutators with respect to the weighted VMO functions and the commutator of Calderon–Zygmund operators on the homogeneous spaces. We will look at the applications of this approach to multilinear Bloom setting.