This presentation introduces a framework for prioritizing investments in emerging infectious disease (EID) vaccine development within a newly established, international multi-stakeholder setting. Drawing from established approaches in the fields of Health Research Priority Setting, Decision Analysis and Operations Research, a conceptual frame is proposed for addressing interconnected problems of strategic objective setting, investment boundary setting, project and portfolio selection. Specific prioritization models are then presented to illustrate how solutions can be supported to each of these problems in a real-life setting, including multi-criteria decision analysis, Monte Carlo simulation and simulation-optimization methods.