Loop (or Dyson-Schwinger) equation is an important tool to study the global fluctuations of one dimensional log-gas type interacting particle systems. In this talk I will present a dynamical version of loop equations for large families of two dimensional interacting particle systems. Some examples include Dyson’s Brownian motion, Nonintersecting Bernoulli/Poisson random walks, corner process, measures on Gelfand-Tsetlin patterns and Macdonald process. Then I will explain how to use dynamical loop equations to understand global fluctuations of these systems. This is a joint work with Vadim Gorin.