Jill Mesirov University of California, San Diego (UCSD) Center for Genome Research The acceleration of data acquisition and the availability of increasing amounts of both genetic and functional data, is changing the face of biomedical research. Computational approaches can take advantage of these data and bring the promise of improved understanding and treatment of disease. We will describe some of the methods and recent discoveries that are helping to better understand and treat cancer, and their translation to the clinic.