Ulugbek Kamilov Washington University in St. Louis There is a growing need in biological, medical, and materials imaging research to recover information lost during data acquisition. There are currently two distinct viewpoints on addressing such information loss: model-based and learning-based. Model-based methods leverage analytical signal properties (such as wavelet sparsity) and often come with theoretical guarantees and insights. Learning-based methods leverage flexible representations (such as convolutional neural nets) for best empirical performance through training on big datasets. The goal of this talk is to introduce a framework that reconciles both viewpoints by providing the "deep learning" counterpart of the classical optimization theory. This is achieved by specifying “denoising deep neural nets” as a mechanism to infuse learned priors into recovery problems, while maintaining a clear separation between the prior and physics-based acquisition models. Our methodology can fully leverage the flexibility offered by deep learning by designing learned denoisers to be used within our new family of fast iterative algorithms. Yet, our results indicate that the such algorithms can achieve state-of-the-art performance in different computational imaging tasks, while also being amenable to rigorous theoretical analysis. We will focus on the application of the methodology to the problem to various biomedical imaging modalities, such as magnetic resonance imaging and optical tomographic microscopy. This talk will be based on the following references: Y. Sun, B. Wohlberg, and U. S. Kamilov, “An Online Plug-and-Play Algorithm for Regularized Image Reconstruction,” IEEE Trans. Comput. Imag., 2019. https://ieeexplore.ieee.org/document/8616843 Y. Sun, J. Liu, and U. S. Kamilov, “Block Coordinate Regularization by Denoising,” Proc. Ann. Conf. Neural Information Processing Systems (NeurIPS 2019) (Vancouver, Canada, Dec 8-14). http://papers.nips.cc/paper/8330-block-coordinate-regularization-by-denoising.pdf Z. Wu, Y. Sun, J. Liu, and U. S. Kamilov, “Online Regularization by Denoising with Applications to Phase Retrieval,” Proc. IEEE Int. Conf. Comp. Vis. Workshops (ICCVW 2019) (Seoul, South Korea, Oct 27 – Nov 2). http://openaccess.thecvf.com/content_ICCVW_2019/html/LCI/Wu_Online_Regularization_by_Denoising_with_Applications_to_Phase_Retrieval_ICCVW_2019_paper.html