Tuberculosis (TB) remains a major public health threat globally, and several studies have demonstrated a role for human genetic factors underlying TB risk. However, exposure to the causal bacterium, Mycobacterium tuberculosis, is a necessary risk factor for TB, and few population-based studies appropriately account for this exposure. In this talk, I will describe how we’ve utilized a family study to examine the genetic epidemiology of TB and address limitations in the extant literature. I will present both key findings and future directions.