Jean-pierre Hubaux École Polytechnique Fédérale de Lausanne (EPFL) P4 medicine is around the corner, fueled notably by the immense progress achieved on the front of genome sequencing. This is clearly a desirable evolution, but the security and privacy implications absolutely need to be tackled. In this talk, we will mention the numerous threats induced by P4 medicine in general (including the “quantified self”) and by genomics in particular. Moreover, we will discuss possible IT architectures for genomic (and phenotypic) data generation, processing, and protection, and present the solutions we have developed in close collaboration with our medical partners, notably MedCo: http://www.genopri.org/uploads/3/9/9/9/39999711/genopri17_paper_6.pdf We will also present the Swiss Personalized Health Network and the recently accepted 3-years grant proposal “Data Protection for Personalized Health” (DPPH) that we will lead. DPPH aims at the privacy-conscious sharing of data between Swiss hospitals and beyond, with an initial focus on oncological data. We will also mention the need for standardization and the security-related activities of the Global Alliance for Genomics and Health (GA4GH). The community Web site we have set up on the topic of genome privacy and security can be found at: https://genomeprivacy.org The workshop we have set up on the topic is GenoPri: http://www.genopri.org An event devoted to secure, privacy-conscious data sharing will take place at EPFL on February 15: http://dpph18.epfl.ch