This talk is focused on recent developments within the field of topoly optimization, e.g. optimal material distribution. The main focus concerns the current state-of-the-art, which is that large structural systems has until now been dealing mainly with the design of individual parts - and not with complete assemblies or structures. In this talk the possibilities when circumventing this limitation is addressed, and examples of giga-voxel structural optimization is shown. The talk includes highlights on designing for additive manufacturing, interactive and real-time structural optimization, non-linear multi-physics and the design of a full scale wing structure.